Two members from each tribe were killed in an armed clash between two groups of Dahani and Jeeha clans near Town Madeji in Shikarpur, reported 24NewsHD TV channel on Thursday.
The bodies were later shifted to a local hospital.
Police said that both the sides used sophisticated weapons.
They said that one of the slain persons was identified as Gulzar Kikrani while identity of the other was being established.
The Force further said that a heavy police contingent had been sent to the scene of the incident, while further investigation was underway.
Around three weeks ago, two people had been killed in a clash between two groups of these same tribes near Town Madeji in Shikarpur.
Although a heavy contingent of police reached site of the incident to calm down the situation, still the exchange of fire between the two groups continued even in its presence.
Police said that the incident was the consequence of old enmity.
A day earlier, four people, including a woman, were killed and five others, including two women, were injured when two groups of Kosh tribe clashed in Khair Muhammad Kosh, a suburban village of Shikarpur, also over old enmity.
Reporter: Abdul Jabbar Abro