Pakistan Muslim League-Nawaz leader Maryam Nawaz will perform Umrah with her family members, 24NewsHD TV channel reported on Monday.
Saudi Airlines flight SV 739 will take the family to Jeddah.
Her spouse Safdar, son and other family members are too leaving for the Kingdom.
Maryam will spend the last days of the holy month of Ramazan there.
She will have a meeting with ex-PM Nawaz Sharif there.
Maryam Nawaz and Nawaz Sharif will be special guests of the royal family in Saudi Arabia.
Nawaz Sharif and Maryam Nawaz will also hold meetings with the Saudi royal leadership, sources said.