At least six people were killed in a firefight between the Juneja and Kalhora tribes in Shikarpur, the 24NewsHDTV channel reported.
The Sindh Police stated that the clash started over a matter of theft.
The groups also used RPGs (rocket propelled grenades) in the crossfire.
The police immediately reached the spot and tried to take control of the situation.
The bodies were identified as those of Nadir Kalhora, Nazar Muhammad Junejo, Sahan, Niaz, and Abdul Karim Junejo.