US Secretary of State Antony Blinken visited Qatar on Tuesday on his latest Middle East crisis tour, seeking a new ceasefire and "an enduring end" to the Israel-Hamas war.
The US top envoy was later bound for Israel, hoping to shore up support for a truce deal that was hashed out in Paris in January but has not yet been signed off on by either Hamas or Israel.
Heavy strikes and fighting in Gaza killed at least 107 people in 24 hours, said the health ministry in the Hamas-ruled territory that has been under almost four months of bombardment.
Fears grew for more than a million Palestinians crowded into the far southern Rafah area as the battlefront draws ever closer in Israel's campaign to eradicate Hamas over the October 7 attack.
Israeli Defence Minister Yoav Gallant warned on Monday that the military "will reach places where we have not yet fought... right up to the last Hamas bastion, which is Rafah", on the Egyptian border.
Palestinian Raed al-Bardani, 32, who has been displaced multiple times and now lives in Rafah with his wife and four children, charged that "the goal is to destroy Rafah because it is the only area that the occupation has not yet destroyed".
"Where will we go if they storm Rafah?" he asked.
Blinken -- on his fifth regional tour since the bloodiest ever Gaza war broke out -- earlier met Egyptian President Abdel Fattah al-Sisi in Cairo, a day after he held talks with Saudi Crown Prince Mohammed bin Salman in Riyadh.
Blinken and Sisi "discussed ongoing efforts to secure the release of all hostages held by Hamas," said State Department spokesperson Matthew Miller.
The US envoy also "expressed appreciation for Egypt's leadership role in facilitating the delivery of humanitarian assistance to Palestinians in Gaza".
And Blinken emphasised Washington's "rejection of any forced displacement of Palestinians from Gaza and commitment to establishing a Palestinian state that provides peace and security for Israelis and Palestinians alike", Miller said.
- 'Beyond catastrophic' -
Israeli troops, with air and naval support, have been engaged in heavy combat centred on Gaza's main southern city of Khan Yunis, the hometown of Hamas's Gaza chief, Yahya Sinwar, much of which has been reduced to rubble.
Israel accuses Sinwar of masterminding the October 7 attack, which resulted in the deaths of about 1,160 people, mostly civilians, according to an AFP tally based on official figures.
Militants also seized around 250 hostages. Israel says 132 remain in Gaza including 28 who are believed to have been killed.
Israel's withering military campaign has killed at least 27,585 people in Gaza, mostly women and children, according to the health ministry.
The army said Tuesday that "over the past day, dozens of terrorists have been killed and approximately 80 individuals suspected of involvement in terrorist activity have been apprehended, including a number of terrorists that took part in the October 7 massacre".
"No place is safe, no place at all -- where shall we go?" one Palestinian, Mohamad Kozaat, said after six members of his family were wounded in an Israeli strike on Rafah.
"The humanitarian situation in the Gaza Strip is beyond catastrophic," said Tommaso Della Longa, spokesman for the International Federation of Red Cross and Red Crescent Societies.
He said around 8,000 displaced people had been evacuated from the besieged Al-Amal hospital in Khan Yunis, where they had sought refuge, after weeks of heavy shelling and fighting nearby.
The United States has strongly backed its top regional ally Israel with munitions and diplomatic support, but also urged steps to reduce civilian casualties.
The truce Blinken is hoping to seal proposes a six-week pause to fighting as Hamas frees hostages in exchange for Palestinian prisoners held by Israel and more aid for Gaza, according to a Hamas source.
Israeli Prime Minister Benjamin Netanyahu, who has faced divisions within his cabinet and public fury over the fate of the remaining hostages, said Israel "will not accept" demands Hamas has made for an exchange involving thousands of prisoners.
- Huthi attacks -
As the Gaza war has raged, violence has also flared in Lebanon, Iraq, Syria and Yemen, where Iran-backed groups have launched attacks in support of Hamas, triggering counterattacks by Israel and the United States and its partners.
Dutch Foreign Minister Hanke Bruins Slot, on a visit to Iraq, recalled that US President Joe Biden had "made it clear not to seek further escalation, and that is crucial. I call on all actors to do the same."
The Israeli army said strikes from Lebanon lightly wounded two soldiers and that it retaliated with artillery "and struck the sources of the fire". Its fighter jets had also targeted Hezbollah bases near Marwahin and Meiss El Jabal in southern Lebanon.
Yemen's Iran-backed Huthis have for weeks been targeting what they say are Israel-linked ships in the Red Sea and Gulf of Aden in solidarity with Palestinians.
The attacks have disrupted global trade and prompted reprisals by US and British forces, including strikes on two "explosive-laden drone boats" on Monday, according to the US military.
The Huthis said Tuesday they had struck US and British commercial ships in two separate attacks.
Huthi spokesman Yahya Saree said "the first attack targeted the American ship Star Nasia, while the other targeted the British ship Morning Tide".
Netanyahu vowed on Monday that "a complete victory will deal a fatal blow" not just to Hamas but also to other Iran-backed militant groups across the region.